Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions
Publication date
2020-02-14
Authors
Jong, Jacobus A W
Guo, Yong
Veenhoven, Cas
Moret, Marc-Etienne
van der Zwan, Johan
Lucini Paioni, Alessandra
Baldus, Marc
Scheiner, Karina C
Dalebout, Remco
van Steenbergen, Mies J
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Document Type
Article
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Abstract
For realization of a wearable artificial kidney based on regeneration of a small volume of dialysate, efficient urea removal from dialysate is a major challenge. Here a potentially suitable polymeric sorbent based on phenylglyoxaldehyde (PGA), able to covalently bind urea under physiological conditions, is described. Sorbent beads containing PGA groups were obtained by suspension polymerization of either styrene or vinylphenylethan-1-one (VPE), followed by modification of the aromatic groups of poly(styrene) and poly(VPE) into PGA. It was found that PGA-functionalized sorbent beads had maximum urea binding capacities of 1.4-2.2 mmol/g and removed ∼0.6 mmol urea/g in 8 h at 37 °C under static conditions from urea-enriched phosphate-buffered saline, conditions representative of dialysate regeneration. This means that the daily urea production of a dialysis patient can be removed with a few hundred grams of this sorbent which, is an important step forward in the development of a wearable artificial kidney.
Keywords
chemisorption, dialysis, kinetics, phenylglyoxaldehyde, sorbent, urea, Polymers and Plastics, Process Chemistry and Technology, Organic Chemistry
Citation
Jong, J A W, Guo, Y, Veenhoven, C, Moret, M-E, van der Zwan, J, Lucini Paioni, A, Baldus, M, Scheiner, K C, Dalebout, R, van Steenbergen, M J, Verhaar, M C, Smakman, R, Hennink, W E, Gerritsen, K G F & van Nostrum, C F 2020, 'Phenylglyoxaldehyde-Functionalized Polymeric Sorbents for Urea Removal from Aqueous Solutions', ACS Applied Polymer Materials, vol. 2, no. 2, pp. 515-527. https://doi.org/10.1021/acsapm.9b00948