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Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization

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1_s2.0_S0960982219316896_main.pdf (3.3 MB)

Publication date

2020-03-09

Authors

Cao, YujieISNI 0000000492960649
Lipka, JoannaISNI 0000000419569766
Stucchi, RiccardoISNI 0000000436351611
Burute, MithilaISNI 0000000492852568
Pan, XingxiuISNI 0000000492915178
Portegies, SybrenISNI 0000000492522040
Tas, Roderick PISNI 0000000493299741
Willems, JelmerISNI 0000000492828939
Will, LenaISNI 0000000380724326
Macgillavry, Harold D.ISNI 0000000390498692

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DOI

https://doi.org/10.1016/j.cub.2019.12.056

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Article

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Abstract

Neuronal dendrites are characterized by an anti-parallel microtubule organization. The mechanism that regulates dendritic microtubule organization is still unclear. Cao et al. demonstrate that the microtubule minus-end binding protein CAMSAP2 and kinesin-14 motor KIFC3 work together to organize dendritic microtubules and control dendrite branching.

Keywords

CAMSAP2, dendrite, KIFC3, kinesin, MAP, microtubule minus-end, microtubule organization, motor protein, neuron, General Biochemistry,Genetics and Molecular Biology, General Agricultural and Biological Sciences

Citation

Cao, Y, Lipka, J, Stucchi, R, Burute, M, Pan, X, Portegies, S, Tas, R, Willems, J, Will, L, MacGillavry, H, Altelaar, M, Kapitein, L C, Harterink, M & Hoogenraad, C C 2020, 'Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization', Current Biology, vol. 30, no. 5, pp. 899-908.e6. https://doi.org/10.1016/j.cub.2019.12.056

URI

http://hdl.handle.net/1874/408493