Structural domain plasticity drives Zn(ii) distribution and buffering in metallothionein-3
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Publication date
2026
Authors
Peris-Díaz, Manuel David
Ebberink, Eduard H T M
Fiala, Jan
Heck, Albert J R
Krężel, Artur
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Document Type
Article
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Abstract
Complementary mass spectrometry-based approaches and molecular dynamics simulations were integrated to map Zn(ii) distribution in partially metalated Zn4–6-metallothionein-3 species relevant to zinc metabolism. Sequential Zn(ii) dissociation engages both the α- and β-domains through a structurally plastic, interdomain mechanism that underpins regulatory zinc buffering at physiological pZn.
Keywords
Electronic, Optical and Magnetic Materials, Catalysis, Ceramics and Composites, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Materials Chemistry
Citation
Peris-Díaz, M D, Ebberink, E H T M, Fiala, J, Heck, A J R & Krężel, A 2026, 'Structural domain plasticity drives Zn(ii) distribution and buffering in metallothionein-3', Chemical Communications, vol. 62, no. 35, pp. 8942-8946. https://doi.org/10.1039/d6cc00567e