Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever
Publication date
2021-07
Authors
Buijs, Sheila B
Stuart, Sanne K
Oosterheert, Jan J.
Karhof, Steffi
Hoepelman, Andy
Renders, Nicole H M
van Petersen, André S
Bleeker-Rovers, Chantal P
Wever, Peter C
Koning, Olivier H J
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by
Abstract
We evaluated the long-term serological follow-up of patients with vascular risk factors for chronic Q fever that were previously Coxiella burnetii seropositive. C. burnetii phase I IgG titers were reevaluated in patients that gave informed consent or retrospectively collected in patients already deceased or lost to follow-up. Of 107 patients, 25 (23.4%) became seronegative, 77 (72.0%) retained a profile of past resolved Q fever infection, and five (4.7%) developed chronic Q fever. We urge clinicians to stay vigilant for chronic Q fever beyond two years after primary infection and perform serological testing based on clinical presentation.
Keywords
Aneurysm, Blood vessel prosthesis, Coxiella burnetii, Q fever, Serology, Microbiology (medical), Infectious Diseases, Journal Article
Citation
Buijs, S B, Stuart, S K, Oosterheert, J J, Karhof, S, Hoepelman, A I M, Renders, N H M, van Petersen, A S, Bleeker-Rovers, C P, Wever, P C & Koning, O H J 2021, 'Long-term serological follow-up after primary Coxiella burnetii infection in patients with vascular risk factors for chronic Q fever', European Journal of Clinical Microbiology & Infectious Diseases, vol. 40, no. 7, pp. 1569-1572. https://doi.org/10.1007/s10096-021-04179-5