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Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

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Publication date

2016

Authors

Schizophrenia Working Group of the Psychiatric Genomics Consortium
ENIGMA2 Consortium
Abramovic, LucijaISNI 0000000387248668
Boks, M. P MORCID 0000-0001-6163-7484ISNI 0000000392872246
van Eijk, Kristel R.ISNI 0000000392803590
Van Haren, N. E MISNI 0000000396766846
Brouwer, Rachel MISNI 0000000389353779

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DOI

https://doi.org/10.1038/nn.4228

Document Type

Article

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Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Keywords

Brain, Endophenotypes, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Linkage Disequilibrium, Magnetic Resonance Imaging, Neuroimaging, Organ Size, Polymorphism, Single Nucleotide, Schizophrenia, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Citation

Schizophrenia Working Group of the Psychiatric Genomics Consortium, ENIGMA2 Consortium, Abramovic, L, Boks, M P, van Eijk, K R, van Haren, N E M & Brouwer, R M 2016, 'Genetic influences on schizophrenia and subcortical brain volumes : large-scale proof of concept', Nature Neuroscience, vol. 19, no. 3, pp. 420-431. https://doi.org/10.1038/nn.4228

URI

http://hdl.handle.net/1874/345855