Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer
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Publication date
2019-11
Authors
Karsten, Rebecca T
Al-Mamgani, Abrahim
Bril, Sandra I.
Tjon-A-Joe, Sheena
van der Molen, Lisette
de Boer, Jan P
Hilgers, Frans J M
Smeele, Ludi E
van den Brekel, Michiel W M
Stuiver, Martijn M
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Article
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taverne
Abstract
BACKGROUND: Sarcopenia might be a relevant lead for optimization of the condition of patients with head and neck cancer (HNC) before chemoradiotherapy (CRT) to prevent long-term functional swallowing impairment, such as feeding tube dependency. METHODS: Regression analyses were performed to assess the association between skeletal muscle mass index (SMI), as a measure of sarcopenia, and prolonged (>90 days) feeding tube dependency in 128 patients with HNC treated with primary CRT. RESULTS: Sixty-one patients (48%) became prolonged feeding tube-dependent. Lower SMI increased the risk of prolonged feeding tube dependency in multivariable analysis (risk ratio 1.08; 95% confidence interval 1.02-1.14, P = .01) adjusted for body mass index, abnormal diet, and socioeconomic status. CONCLUSIONS: Sarcopenia contributes to the risk of prolonged feeding tube dependency of patients with HNC treated with primary CRT. As sarcopenia might be a modifiable factor prior to treatment, it should be explored as a target for pretreatment patients' condition.
Keywords
chemoradiotherapy, head and neck cancer, sarcopenia, skeletal muscle mass, tube feeding, Taverne, Otorhinolaryngology
Citation
Karsten, R T, Al-Mamgani, A, Bril, S I, Tjon-A-Joe, S, van der Molen, L, de Boer, J P, Hilgers, F J M, Smeele, L E, van den Brekel, M W M & Stuiver, M M 2019, 'Sarcopenia, a strong determinant for prolonged feeding tube dependency after chemoradiotherapy for head and neck cancer', Head & neck, vol. 41, no. 11, pp. 4000-4008. https://doi.org/10.1002/hed.25938