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Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding

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Publication date

2016-08-04

Authors

Drost, Jarno
Clevers, HansISNI 0000000043961208

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DOI

https://doi.org/10.1016/j.molcel.2016.07.013

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Article

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taverne

Abstract

Intratumor heterogeneity is thought to be the driving force of tumor evolution and therapy resistance. Yet tools to study these processes are limited. In this issue, Guernet et al. (2016) devised clustered regularly interspaced short palindromic repeats (CRISPR)-barcoding to functionally annotate specific mutations and study clonal evolution in heterogeneous cell populations.

Keywords

Taverne, Molecular Biology, Cell Biology, Journal Article

Citation

Drost, J & Clevers, H 2016, 'Who Is in the Driver's Seat : Tracing Cancer Genes Using CRISPR-Barcoding', Molecular Cell, vol. 63, no. 3, pp. 352-354. https://doi.org/10.1016/j.molcel.2016.07.013

URI

https://dspace.library.uu.nl/handle/1874/346651