Behandeling van intoxicatie met paracetamol: Rekening houden met dosis, toedienings vorm en risicofactoren

Abstract

Paracetamol is the drug for which the Dutch Poisons Information Centre (DPIC) receives the most information requests. The protocol for the treatment of single acute oral paracetamol intoxications is clear, however, ambiguity exists concerning the treatment of intoxications with repeated supratherapeutic doses of paracetamol. Paracetamol intoxications with liquid preparations, extendedrelease tablets, exposure routes other than oral, and repeated supratherapeutic ingestions require a tailored approach. An increased risk of liver damage due to paracetamol intoxication has to be taken into account for patients who consume excessive levels of alcohol, are malnourished or have a preexisting liver condition. The decision tree of the DPIC is a helpful tool to swiftly attain a risk assessment and treatment plan for most types of paracetamol intoxication. Conflict of interest and financial support: none declared.