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Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?

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Publication date

2016-07-01

Authors

Rasmussen, Hans
Frokjaer, Vibe G.
Hilker, Rikke W.
Madsen, Jacob
Anhøj, Simon
Oranje, BobISNI 0000000387484580
Pinborg, Lars H.
Glenthøj, Birte
Knudsen, Gitte M.

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DOI

https://doi.org/10.1016/j.euroneuro.2016.04.008

Document Type

Article

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Abstract

Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia.

Keywords

Clinical Neurology, Psychiatry and Mental health, Pharmacology (medical), Biological Psychiatry, Neurology, Pharmacology, Journal Article

Citation

Rasmussen, H, Frokjaer, V G, Hilker, R W, Madsen, J, Anhøj, S, Oranje, B, Pinborg, L H, Glenthøj, B & Knudsen, G M 2016, 'Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?', European Neuropsychopharmacology, vol. 26, no. 7, pp. 1248-1250. https://doi.org/10.1016/j.euroneuro.2016.04.008

URI

http://hdl.handle.net/1874/345336