Initial Results of Secukinumab Drug Survival in Patients with Psoriasis: A Multicentre Daily Practice Cohort Study
Publication date
2018-07-11
Authors
van den Reek, Juul M P A
van Vugt, Lieke J
van Doorn, Martijn B A
van der Kraaij, Gayle E
de Kort, Wim J A
Lucker, Georges P H
Horvath, Barbara
Njoo, M David
Bovenschen, H Jorn
Ossenkoppele, Paul M
Editors
Advisors
Supervisors
Document Type
Article
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cc_by_nc
Abstract
Interleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials. However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice. The aim of this study was to evaluate drug survival of secukinumab in a daily practice psoriasis cohort. Data were collected from 13 hospitals. Drug survival was analysed using Kaplan-Meier survival curves, split for reason of discontinuation. In total, 196 patients were included (83% biologic experienced). Overall, 12 and 18 months drug survival of secukinumab was 76% and 67%, respectively, and was mostly determined by ineffectiveness. There was a trend towards shorter drug survival in women and in biologic experienced patients. Thirteen percent of patients experienced at least one episode of fungal infection. This is one of the first studies of drug survival of secukinumab in patients with psoriasis treated in daily practice.
Keywords
Adult, Antibodies, Monoclonal, Humanized, Antibodies, Monoclonal/adverse effects, Dermatologic Agents/adverse effects, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Netherlands, Proportional Hazards Models, Psoriasis/diagnosis, Retrospective Studies, Time Factors, Treatment Outcome, Journal Article, Multicenter Study
Citation
van den Reek, J M P A, van Vugt, L J, van Doorn, M B A, van der Kraaij, G E, de Kort, W J A, Lucker, G P H, Horvath, B, Njoo, M D, Bovenschen, H J, Ossenkoppele, P M, De Bruin-Weller, M S, de Groot, M, Mommers, R, Prevoo, R L M A, van de Kerkhof, P C M, Spuls, P I, Kievit, W & de Jong, E M G J 2018, 'Initial Results of Secukinumab Drug Survival in Patients with Psoriasis : A Multicentre Daily Practice Cohort Study', Acta Dermato-Venereologica, vol. 98, no. 7, pp. 648-654. https://doi.org/10.2340/00015555-2900