Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles
Publication date
2015-01-01
Authors
Shi, Yang
Cardoso, Renata M.
van Nostrum, Rene
Hennink, Wim E
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Advisors
Supervisors
Document Type
Article
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Abstract
An anthracene-functionalized thermosensitive block copolymer was synthesized, which formed micelles by heating its aqueous solution above the lower critical solution temperature (LCST). The micelles were subsequently crosslinked by UV illumination at 365 nm with a normal handheld UV lamp. The micelles showed a small size (30 nm) and high loading capacity (16.0 ± 0.1%) for paclitaxel and released paclitaxel for more than ten days.
Keywords
Polymers and Plastics, Organic Chemistry, Biochemistry, Biomedical Engineering, Bioengineering
Citation
Shi, Y, Cardoso, R M, Van Nostrum, C F & Hennink, W E 2015, 'Anthracene functionalized thermosensitive and UV-crosslinkable polymeric micelles', Polymer Chemistry, vol. 6, no. 11, pp. 2048-2053. https://doi.org/10.1039/c4py01759e