Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy: a case report of a 27-year-old woman
Publication date
2017-09
Authors
de Jong, Corine
Sanders, Stefan
Creemers, Geert-Jan
Burylo, Artur M
Taks, Margot
Schellens, Jan H M
Deenen, Maarten J
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Supervisors
Document Type
Article
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taverne
Abstract
In this report we describe a young patient diagnosed with bulky FIGO stage IIIb squamous cell cervix carcinoma with severe and irreversible nephropathy after three weekly low-doses of cisplatin. Besides several known risk factors such as hypomagnesemia and hypoalbuminemia, the patient also proved to be homozygously polymorphic for two polymorphisms within the COMT gene (c.615 + 310C>T and c.616-367C>T). As COMT polymorphism has been associated with cisplatin-induced ototoxicity, its effect on nephrotoxicity of cisplatin should be the subject of further investigation.
Keywords
cisplatin, genotyping, nephrotoxicity, pharmacogenomics, case reports, Taverne
Citation
de Jong, C, Sanders, S, Creemers, G-J, Burylo, A M, Taks, M, Schellens, J H M & Deenen, M J 2017, 'Pharmacogenetic analysis of irreversible severe cisplatin-induced nephropathy : a case report of a 27-year-old woman', British Journal of Clinical Pharmacology, vol. 83, no. 9, pp. 2120-2122. https://doi.org/10.1111/bcp.13309