M3: an integrative framework for structure determination of molecular machines
Files
Publication date
2017
Authors
Karaca, E.
Garcia Lopes Maia Rodrigues, João
Graziadei, Andrea
Bonvin, A.M.J.J.
Carlomagno, Teresa
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
We present a broadly applicable, user-friendly protocol that incorporates sparse and hybrid experimental data to calculate quasi-atomic-resolution structures of molecular machines. The protocol uses the HADDOCK framework, accounts for extensive structural rearrangements both at the domain and atomic levels and accepts input from all structural and biochemical experiments whose data can be translated into interatomic distances and/or molecular shapes.
Keywords
Taverne
Citation
Karaca, E, Garcia Lopes Maia Rodrigues, J, Graziadei, A, Bonvin, A M J J & Carlomagno, T 2017, 'M3: an integrative framework for structure determination of molecular machines', Nature Methods, vol. 14, no. 9, pp. 897-902. https://doi.org/10.1038/nmeth.4392