Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease: A Pilot Study
Publication date
2017
Authors
Bouvy, Willem H.
Kuijf, Hugo J.
Zwanenburg, J. J.M.
Koek, Huiberdina L.
Kappelle, Jaap
Luijten, Peter
Ikram, M Kamran
Biessels, Geert Jan
Utrecht Vascular Cognitive Impairment (VCI) Study group
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
Cerebral small vessel disease (SVD) contributes to cognitive impairment and dementia. SVD may affect veins, but veins are difficult to detect with 1.5 and 3T MRI. We compared deep medullary veins (DMVs) visualized on 7T-MRI between patients with early Alzheimer's disease (eAD; n = 17) or amnestic MCI (aMCI; n = 12) and controls (n = 40). The number and density of DMVs was similar in patients and controls, but tortuosity was higher in eAD (Cohen's d=0.7, 95% CI: 0.1-1.2, p=0.02) and aMCI (Cohen's d = 0.8, 95% CI: 0.2-1.5, p = 0.01), independent of brain atrophy. Venous changes provide a new perspective on vascular involvement in dementia.
Keywords
Alzheimer's disease, cerebral small vessel disease, cerebral veins, magnetic resonance imaging, Taverne, Clinical Psychology, Geriatrics and Gerontology, Psychiatry and Mental health, Journal Article
Citation
Bouvy, W H, Kuijf, H J, Zwanenburg, J J M, Koek, H L, Kappelle, L J, Luijten, P R, Ikram, M K, Biessels, G J & Utrecht Vascular Cognitive Impairment (VCI) Study group 2017, 'Abnormalities of Cerebral Deep Medullary Veins on 7 Tesla MRI in Amnestic Mild Cognitive Impairment and Early Alzheimer's Disease : A Pilot Study', Journal of Alzheimer's Disease, vol. 57, no. 3, pp. 705-710. https://doi.org/10.3233/JAD-160952