Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish
Publication date
2018-07-03
Authors
Ferrero, Giuliano
Mahony, Christopher B.
Dupuis, Eléonore
Yvernogeau, Laurent
Di Ruggiero, Elodie
Miserocchi, Magali
Caron, Marianne
Robin, Catherine
Traver, David
Bertrand, Julien Y.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by_nc_nd
Abstract
Using zebrafish to investigate microglia ontogeny during vertebrate development, Ferrero et al. find that embryonic “primitive” microglia exclusively derive from primitive macrophages, while adult “definitive” microglia originate from cmyb-dependent hematopoietic stem cells.
Keywords
cmyb, developmental hematopoiesis, erythro-myeloid progenitors, fate mapping, hematopoietic stem cells, microglia, ontogeny, primitive macrophages, General Biochemistry,Genetics and Molecular Biology
Citation
Ferrero, G, Mahony, C B, Dupuis, E, Yvernogeau, L, Di Ruggiero, E, Miserocchi, M, Caron, M, Robin, C, Traver, D, Bertrand, J Y & Wittamer, V 2018, 'Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish', Cell Reports, vol. 24, no. 1, pp. 130-141. https://doi.org/10.1016/j.celrep.2018.05.066