Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products
Publication date
2019-06-01
Authors
Brouwer, Michael S.M.
Tehrani, Kamaleddin H.M.E.
Rapallini, Michel
Geurts, Yvon
Kant, Arie
Harders, Frank
Mashayekhi, Vida
Martin, Nathaniel I
Bossers, Alex
Mevius, Dik
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Document Type
Article
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Abstract
Food for human consumption is screened widely for the presence of antibiotic-resistant bacteria to assess the potential for transfer of resistant bacteria to the general population. Here, we describe an Enterobacter cloacae complex isolated from imported seafood that encodes two carbapenemases on two distinct plasmids. Both enzymes belong to Ambler class A -lactamases, the previously described IMI-2 and a novel family designated FLC-1. The hydrolytic activity of the novel enzyme against aminopenicillins, cephalosporins, and carbapenems was determined.
Keywords
Antimicrobial resistance, Carbapenemase, Enterobacter, Plasmid, Pharmacology, Pharmacology (medical), Infectious Diseases, SDG 3 - Good Health and Well-being
Citation
Brouwer, M S M, Tehrani, K H M E, Rapallini, M, Geurts, Y, Kant, A, Harders, F, Mashayekhi, V, Martin, N I, Bossers, A, Mevius, D J, Wit, B & Veldman, K T 2019, 'Novel carbapenemases FLC-1 and IMI-2 encoded by an enterobacter cloacae complex isolated from food products', Antimicrobial Agents and Chemotherapy, vol. 63, no. 6, e02338-18. https://doi.org/10.1128/AAC.02338-18