Emerging roles of cohesin-STAG2 in cancer
Publication date
2025-02-18
Authors
Scott, Julia S
Al Ayadi, Loubna
Epeslidou, Emmanouela
van Scheppingen, Roan H.
Mukha, Anna
Kaaij, Lucas J.T.
Lutz, Catrin
Prekovic, Stefan
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Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Cohesin, a crucial regulator of genome organisation, plays a fundamental role in maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 stands out because of its frequent deleterious mutations in various cancer types, such as bladder cancer and melanoma. Loss of STAG2 function leads to significant alterations in chromatin structure, disrupts transcriptional regulation, and impairs DNA repair pathways. In this review, we explore the molecular mechanisms underlying cohesin-STAG2 function, highlighting its roles in healthy cells and its contributions to cancer biology, showing how STAG2 dysfunction promotes tumourigenesis and presents opportunities for targeted therapeutic interventions.
Keywords
Taverne, Molecular Biology, Genetics, Cancer Research
Citation
Scott, J S, Al Ayadi, L, Epeslidou, E, van Scheppingen, R H, Mukha, A, Kaaij, L J T, Lutz, C & Prekovic, S 2025, 'Emerging roles of cohesin-STAG2 in cancer', Oncogene, vol. 44, no. 5, 70, pp. 277–287. https://doi.org/10.1038/s41388-024-03221-y