Computational modeling of plant root development: the art and the science

Abstract

Plant root development, like any developmental process, arises from the interplay between processes like gene expression, cell-cell signaling, cell growth and division, and tissue mechanics, which unfold over a wide range of temporal and spatial scales. Computational models are uniquely suited to integrate these different processes and spatio-temporal scales to investigate how their interplay determines developmental outcomes and have become part of mainstream plant developmental research. Still, for non-modeling experts, it often remains unclear how models are built, why a particular modeling approach was chosen, and how to interpret and value model outcomes. This review attempts to explain the science behind the art of model building, illustrating the simplifications that are often made to keep models simple to understand and when these are and are not justified. Similarly, it discusses when it is safe to ignore certain processes like growth or tissue mechanics and when it is not. Additionally, this review discusses a range of major breakthrough modeling articles. Their approaches are linked to classical concepts and models in developmental biology like the French flag positional information gradient of Lewis Wolpert and the repetitive patterning mechanism proposed by Turing, in addition to highlighting the lessons they taught us on plant root development.