CAG-repeats in the androgen receptor gene relate with plasma androgen levels in the Bouvier Des Flandres

Abstract

BACKGROUND: The Bouvier des Flandres (BdF) dog is predisposed to develop prostate carcinoma (PCA). In humans, ethnic groups with higher prevalence of PCA have higher serum androgens concentrations and shorter polyglutamine (CAG) repeat lengths in the androgen receptor (AR) gene. In dogs, shorter CAG-I lengths are associated with increased PCA risk. OBJECTIVE: To compare serum androgens concentrations in the BdF with other breeds and to determine whether CAG repeats length and plasma androgens concentrations are correlated. MATERIALS AND METHODS: Androgens were measured in 46 BdF and in 53 other dog breed. Length of CAG-I and CAG-III repeats were measured in 41 BdF and correlated with androgen levels. RESULTS: In the BdF group shorter CAG-I and longer CAG-III repeat lengths were associated with lower androgen concentrations. CONCLUSION: As the shorter CAG-I repeat is associated with an increased PCA risk, higher androgen concentrations may protect against the development and progression of PCA.