Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C
Publication date
2013
Authors
Ulferts, R.
Jan Thibaut, Hendrik
Lanke, K.H.W.
Leyssen, P.
Coutard, B.
De Palma, A.M.
Canard, B.
Neyts, J.
van Kuppeveld, Frank J M
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Document Type
Article
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Abstract
Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)—a selective serotonin reuptake inhibitor—inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.
Keywords
Coronacrisis-Taverne
Citation
Ulferts, R, Thibaut, H J, Lanke, K H W, Leyssen, P, Coutard, B, De Palma, A M, Canard, B, Neyts, J & van Kuppeveld, F J M 2013, 'Selective serotonin reuptake inhibitor fluoxetine inhibits replication of human enterovirus B and D by targeting viral protein 2C', Antimicrobial Agents and Chemotherapy, vol. 57, no. 4, pp. 1952-1956. https://doi.org/10.1128/AAC.02084-12