Evaluation of the detection rate of hemophilia carriers
Publication date
1975-08
Authors
Bouma, B.N.
Klaauw, M.M. van der
Veltkamp, J.J.
Starkenburg, A.E.
Tilburg, N.H. van
Hermans, J.
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Article
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Abstract
The detection rate of hemophilia A carriers was evaluated on the basis of AHF-activity and AHF-like antigen determination. Statistical tolerance regions were constructed containing 50 and 95% of the AHF-activity and AHF-like antigen determinations of individuals of the normal or carrier group. Using these regions 18 out of 22 obligatory carriers are outside the 95% tolerance region of the normals. On the basis of AHF-activity alone only 8 out of 22 obligatory carriers are outside the 95% tolerance interval for the normals.
For individual counselling for possible or potential carriers, with a prior chance (i.e. genetically determined) on carriership, the probabilities of carriership are calculated with the theorem of Bayes.