European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)
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Publication date
2019-12
Authors
Düzel, Emrah
Acosta-Cabronero, Julio
Berron, David
Biessels, Geert Jan
Björkman-Burtscher, Isabella
Bottlaender, Michel
Bowtell, Richard
Buchem, Mark V
Cardenas-Blanco, Arturo
Boumezbeur, Fawzi
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Article
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Abstract
Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration. EUFIND comprises 22 European and one US site, including over 50 MRI and dementia experts as well as neuroscientists. Methods: EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular systems/vascular pathology, iron mapping and neuropathology detection, spectroscopy, and quality assurance. Across these topics, EUFIND considered standard operating procedures, safety, and multivendor harmonization. Results: The clinical and research opportunities and challenges of 7T MRI in each subtopic are set out as a roadmap. Specific MRI sequences for each subtopic were implemented in a pilot study presented in this report. Results show that a large multisite 7T imaging network with highly advanced and harmonized imaging sequences is feasible and may enable future multicentre ultrahigh-field MRI studies and clinical trials. Discussion: The EUFIND network can be a major driver for advancing clinical neuroimaging research using 7T and for identifying use-cases for clinical applications in neurodegeneration.
Keywords
Alzheimer's disease (AD), Magnetic resonance imaging (MRI), Mild cognitive impairment (MCI), Parkinson's disease (PD), Subjective cognitive decline (SCD), Ultrahigh-field MRI, Vascular dementia, Clinical Neurology, Psychiatry and Mental health
Citation
Düzel, E, Acosta-Cabronero, J, Berron, D, Biessels, G J, Björkman-Burtscher, I, Bottlaender, M, Bowtell, R, Buchem, M V, Cardenas-Blanco, A, Boumezbeur, F, Chan, D, Clare, S, Costagli, M, de Rochefort, L, Fillmer, A, Gowland, P, Hansson, O, Hendrikse, J, Kraff, O, Ladd, M E, Ronen, I, Petersen, E, Rowe, J B, Siebner, H, Stoecker, T, Straub, S, Tosetti, M, Uludag, K, Vignaud, A, Zwanenburg, J & Speck, O 2019, 'European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)', Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 11, pp. 538-549. https://doi.org/10.1016/j.dadm.2019.04.010