Strategies to target drugs to gliomas and CNS metastases of solid tumors
Publication date
2016-03
Authors
Milojkovic Kerklaan, B.
van Tellingen, O.
Huitema, A. D R
Beijnen, Jos H
Boogerd, W.
Schellens, Jan H M
Brandsma, D.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
The treatment for central nervous system metastases of solid tumors and gliomas is limited as the blood–brain barrier (BBB) is an obstacle to systemic therapy. Here, we review the physiochemical properties of the BBB and both current and new drug strategies to penetrate brain tumors. We focus on targeting receptor- or carrier-mediated transport mechanisms over the BBB used by drug conjugates, nanoparticles, polymer-based nanocarriers, siRNA, and antibodies.
Keywords
Antibodies, Brain metastases, Glioma, Nanoparticles, Polymer-based nanocarriers, siRNA, Taverne, Clinical Neurology, Neurology
Citation
Milojkovic Kerklaan, B, van Tellingen, O, Huitema, A D R, Beijnen, J H, Boogerd, W, Schellens, J H M & Brandsma, D 2016, 'Strategies to target drugs to gliomas and CNS metastases of solid tumors', Journal of Neurology, vol. 263, no. 3, pp. 428–440. https://doi.org/10.1007/s00415-015-7919-9