Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors
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Publication date
2013
Authors
Jones, E.A.
Schmitz, N.
Waaijer, C.J.F.
Frese, C.
van Remoortere, A.
van Zeijl, R.J.M.
Heck, Albert J R
Hogendoorn, P.C.W.
Deelder, A.M.
Altelaar, Maarten
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Abstract
Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.
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Jones, E A, Schmitz, N, Waaijer, C J F, Frese, C, van Remoortere, A, van Zeijl, R J M, Heck, A J R, Hogendoorn, P C W, Deelder, A M, Altelaar, A F M, Bovée, J V M G & McDonnell, L A 2013, 'Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors', Journal of Proteome Research, vol. 12, pp. 1847-1855. https://doi.org/10.1021/pr301190g