Primary Graft Dysfunction in Lung Transplantation: An Overview of the Molecular Mechanisms
Publication date
2025-07-15
Authors
Jennekens, Jitte
Braithwaite, S. A.
Luijk, Bart
van der Kaaij, Niels
Vrisekoop, Nienke
Jager, Saskia Christel Antoinette de
de Heer, Linda
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Primary graft dysfunction (PGD) remains a major complication after lung transplantation. Donor lung ischemia followed by reperfusion drives oxidative stress and inflammatory responses. The pathophysiology is influenced by various donor-, procedure-, and recipient-related factors, which complicates the identification of biomarkers for evaluation of donor lung injury or therapeutic interventions to minimize PGD. This review provides an overview of the molecular pathways that contribute to PGD pathophysiology, including those involved in loss of endothelial-epithelial membrane integrity, neutrophil infiltration, and the development of pulmonary edema.
Keywords
Animals, Biomarkers/metabolism, Humans, Lung Transplantation/adverse effects, Lung/metabolism, Oxidative Stress, Primary Graft Dysfunction/etiology, Reperfusion Injury, Journal Article, Review
Citation
Jennekens, J, Braithwaite, S A, Luijk, B, van der Kaaij, N P, Vrisekoop, N, de Jager, S C A & de Heer, L M 2025, 'Primary Graft Dysfunction in Lung Transplantation : An Overview of the Molecular Mechanisms', International Journal of Molecular Sciences, vol. 26, no. 14, 6776. https://doi.org/10.3390/ijms26146776