Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease
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Publication date
2016-04-01
Authors
Severs, Mirjam
van Erp, S. J H
van der Valk, Mirthe E
Mangen, Marie-Josée J
Fidder, Herma H
van der Have, Mike
van Bodegraven, A. A.
de Jong, D. J.
van der Woude, C. J.
Romberg-Camps, M. J L
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Document Type
Article
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Abstract
Background and aims: Smoking affects the course of disease in patients with ulcerative colitis (UC) and Crohn's disease (CD). We aimed to study the association between smoking and extraintestinal manifestations (EIMs) in inflammatory bowel disease (IBD). Methods: We cross-sectionally explored the association between smoking and EIMs in IBD in three cohort studies: (1) the COIN study, designed to estimate healthcare expenditures in IBD; (2) the Groningen study, focused on cigarette smoke exposure and disease behaviour in IBD; and (3) the JOINT study, evaluating joint and back manifestations in IBD. Results: In the COIN, Groningen and JOINT cohorts, 3030, 797 and 225 patients were enrolled, of whom 16, 24 and 23.5% were current smokers, respectively. Chronic skin disorders and joint manifestations were more prevalent in smoking IBD patients than in non-smokers (COIN, 39.1 vs 29.8%, p
Keywords
Extra-intestinal manifestations, Inflammatory bowel disease, Smoking, Gastroenterology, Journal Article, Research Support, Non-U.S. Gov't
Citation
Severs, M, van Erp, S J H, van der Valk, M E, Mangen, M J J, Fidder, H H, van der Have, M, van Bodegraven, A A, de Jong, D J, van der Woude, C J, Romberg-Camps, M J L, Clemens, C H M, Jansen, J M, van de Meeberg, P C, Mahmmod, N, Ponsioen, C Y, Bolwerkm, C, Vermeijden, J R, Pierik, M J, Siersema, P D, Leenders, M, van der Meulen-de Jong, A E, Dijkstra, G & Oldenburg, B 2016, 'Smoking is associated with extra-intestinal manifestations in inflammatory bowel disease', Journal of Crohn's & Colitis, vol. 10, no. 4, pp. 455-461. https://doi.org/10.1093/ecco-jcc/jjv238