General pathophysiology of neuroglia

Abstract

Neuroglia in the CNS, represented by astroglia, oligodendroglia, and microglia, are responsible for the homeostatic support and protection of the nervous tissue. Neuroglia are intimately involved in the pathogenesis of all neurologic diseases, and neuroglial changes to a large extent define the progression of these diseases and their neurologic outcome. In contrast to neurons, neuroglia are capable of mounting an evolutionary conserved response to pathology known as reactive gliosis. Reactive gliosis is initially protective and allostatic, and it is aimed at preserving the nervous tissue function and integrity. However, in many diseases, neuroglial cells undergo atrophy and functional asthenia, contributing to nervous tissue damage.