Gas chromatographic determination of xanthinol in plasma

Abstract

The determination of xanthinol in plasma is described. After extraction of the drug, together with the internal standard (papaverine hydrochloride), the extract is evaporated to dryness and the drug is derivatized with acetic anhydride for chromatography. The method is linear for 2–100μg ml-1 ; the coefficient of variation is 3% and the recovery 80%. The resulting stable solution allows large numbers of samples to be processed with an automatic injector.