Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing IVF/ICSI

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: This review has two objectives. These are: to assess the comparative effectiveness (pregnancy and live birth) and safety (ovarian hyperstimulation syndrome) in women undergoing in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI): of different doses of gonadotropin in women subgrouped by their expected response to stimulation, as defined by at least one ovarian reserve test (ORT) measure (do women with low, moderate or high anticipated response to ovarian stimulation, based on an ORT, benefit from a modified gonadotropin dose?); and of individualisation of gonadotropin dose using ORT, as compared to dose selection without ORT, or to an alternative individualised dosing algorithm using ORT (does using ORT to individualise gonadotropin dose improve IVF/ICSI outcomes, and is there evidence to suggest one algorithm is better than another?).