Phylogenomic Investigation of IncI1-Iγ Plasmids Harboring blaCMY-2 and blaSHV-12 in Salmonella enterica and Escherichia coli in Multiple Countries
Publication date
2019-07
Authors
Castellanos, Luis Ricardo
van Bloois, L.
Donado-Godoy, Pilar
Mevius, Dik
Wagenaar, J.A.
Hordijk, Joost
Zomer, Aldert
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Document Type
Article
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Abstract
The objective of this study was to elucidate the genetic and evolutionary relatedness of blaCMY-2- and blaSHV-12-carrying IncI1-Iγ plasmids. Phylogenomic analysis based on core genome alignments and gene presence/absence was performed for different IncI1-Iγ Sequence Types (STs). Most IncI1-Iγ/ST12 and IncI1-Iγ/ST231 plasmids had near-identical core genomes. The data suggests that widespread occurring blaCMY-2-carrying IncI1-Iγ/ST12 plasmids originate from a common ancestor. In contrast, blaSHV-12 was inserted independently into different IncI1-Iγ/ST231-related plasmids.
Keywords
ISEcp1, IS1294, IS26, sugE, blc, deoR, Salmonella Paratyphi B var. JAva, S. Heidelberg, broiler, chicken, Coronacrisis-Taverne
Citation
Castellanos, L R, van der Graaf-van Bloois, L, Donado-Godoy, P, Mevius, D J, Wagenaar, J A, Hordijk, J & Zomer, A 2019, 'Phylogenomic Investigation of IncI1-Iγ Plasmids Harboring blaCMY-2 and blaSHV-12 in Salmonella enterica and Escherichia coli in Multiple Countries', Antimicrobial Agents and Chemotherapy, vol. 63, no. 7, e02546-18. https://doi.org/10.1128/AAC.02546-18