Stable pattern of HIV-1 subtype C gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians
Publication date
2007
Authors
Tsegaye, A.
Ran, L.J.
Wolday, D.
Petros, B.
Nanlohy, N.M.
Meles, H.
Girma, M.
Hailu, E.
Borghans, J.A.M.
Miedema, F
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Supervisors
Document Type
Article
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Abstract
We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/[mu]l per year) and five with a fast (> 45 cells/[mu]l per year) CD4 T-cell decline longitudinally. Six study subjects had T-cell responses directed to one or more HIV-1 Gag peptides. The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype.
Keywords
Life sciences, Biomathematics and biometrics, Taverne
Citation
Tsegaye, A, Ran, L J, Wolday, D, Petros, B, Nanlohy, N M, Meles, H, Girma, M, Hailu, E, Borghans, J A M, Miedema, F & van Baarle, D 2007, 'Stable pattern of HIV-1 subtype C gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians', AIDS, vol. 21, no. 3, pp. 369-371. https://doi.org/10.1097/QAD.0b013e32801222e3