Membrane domain formation - a key factor for targeted intracellular drug delivery
Publication date
2014
Authors
Popov-Celeketic, Dusan
van Bergen En Henegouwen, Paul M P
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Document Type
Article
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Abstract
Proteinmolecules,toxinsandvirusesinternalizeintothecellviareceptor-mediatedendocytosis(RME)usingspecificproteinsandlipidsintheplasmamembrane.Theplasmamembraneisabarrierformanypharmaceuticalagentstoenterintothecytoplasmoftargetcells.Inthecaseofcancercells,tissue-specificbiomarkersintheplasmamembrane,likecancer-specificgrowthfactorreceptors,couldbeexcellentcandidatesforRME-dependentdrugdelivery.Recentdatasuggestthatagentbindingtothesereceptorsatthecellsurface,resultinginmembranedomainformationbyreceptorclustering,canbeusedfortheinitiationofRME.Asaresult,thesepharmaceuticalagentsareinternalizedintothecellsandfollowdifferentroutesuntiltheyreachtheirfinalintracellulartargetslikelysosomesorGolgi.Weproposethatclusteringinducedformationofplasmamembranemicrodomainsenrichedinreceptors,sphingolipids,andinositollipids,leadstomembranebendingwhichfunctionsastheonsetofRME.InthisreviewwewillfocusontheroleofdomainformationinRMEanddiscusspotentialapplicationsfortargetedintracellulardrugdelivery.
Keywords
membran edomain, receptor mediated endocytosis, EGFR, receptor clustering, drug delivery, cancer therapy, SDG 3 - Good Health and Well-being
Citation
Popov-Celeketic, D & van Bergen en Henegouwen, P 2014, 'Membrane domain formation - a key factor for targeted intracellular drug delivery', Frontiers in Physiology [E], vol. 5, pp. 462. https://doi.org/10.3389/fphys.2014.00462