Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV
Publication date
2025-06-10
Authors
Bjerrum, Stephanie
Yang, Bada
Åhsberg, Johanna
Olbrich, Laura
Damkjær, Mathias Weis
Nathavitharana, Ruvandhi R.
Broger, Tobias
Olaru, Ioana Diana
Sweetser, Brittney
Poore, Hayley
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Objectives: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows:. To compare the diagnostic accuracy of parallel use of lateral flow urine lipoarabinomannan on urine and low-complexity automated nucleic acid amplification tests on respiratory samples versus each test alone for detection of tuberculosis disease in adults and adolescents living with HIV who present with presumptive tuberculosis. Secondary objectives To investigate the following sources of heterogeneity: clinical setting; signs and symptoms of tuberculosis; screening positivity for tuberculosis disease by chest x-ray, C-reactive protein elevation, and molecular World Health Organization-recommended rapid diagnostics; seriously ill; advanced HIV; and CD4 cell count.
Keywords
Taverne, Pharmacology (medical)
Citation
Bjerrum, S, Yang, B, Åhsberg, J, Olbrich, L, Damkjær, M W, Nathavitharana, R R, Broger, T, Olaru, I D, Sweetser, B, Poore, H, Razid, A, Kay, A W, Denkinger, C M, Schiller, I, Dendukuri, N, Jaganath, D, Lundh, A & Shah, M 2025, 'Parallel use of low-complexity automated nucleic acid amplification tests and lateral flow urine lipoarabinomannan assays to detect tuberculosis disease in adults and adolescents living with HIV', Cochrane Database of Systematic Reviews, vol. 2025, no. 5. https://doi.org/10.1002/14651858.CD016070.pub2