PTSD course and predictors in a 15 year longitudinal cohort following suspected serious injury

Publication date

2025-08-07

Authors

Karchoud, Jeanet F
Hoeboer, Chris M
Karaban, Ira
Mouthaan, Joanne
Sijbrandij, Marit
Olff, Miranda
Van de Schoot, R.ORCID 0000-0001-7736-2091ISNI 0000000393562696
van Zuiden, MirjamORCID 0000-0002-1225-2702ISNI 0000000389241136

Editors

Advisors

Supervisors

Document Type

Article
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License

cc_by

Abstract

Investigating long-term posttraumatic stress disorder (PTSD) course and its predictors may guide prevention and early intervention strategies following trauma exposure, potentially reducing the long-lasting impact of trauma. N = 155 emergency-admitted adults with (suspected) serious injury were repeatedly assessed until one-year post-trauma and completed a 12-15 year follow-up including a clinical PTSD interview. Adverse one-year PTSD trajectories; more exposure to additional potentially traumatic events and recent life stressors; and early post-trauma predictors (younger age, greater perceived impact of prior potentially traumatic events, higher heart rate) were significantly associated with higher PTSD symptom severity 12-15 years post-trauma. This study showed high consistency between one-year PTSD and its early post-trauma predictors with long-term PTSD outcomes. Early post-trauma predictors had predictive value up to 12-15 years. This suggests that early risk identification of one-year PTSD and subsequent effective early interventions also hold long-term beneficial effects for PTSD outcome.

Keywords

Neuroscience (miscellaneous), Psychology (miscellaneous), Psychiatry and Mental health, Behavioral Neuroscience

Citation

Karchoud, J F, Hoeboer, C M, Karaban, I, Mouthaan, J, Sijbrandij, M, Olff, M, van de Schoot, R & van Zuiden, M 2025, 'PTSD course and predictors in a 15 year longitudinal cohort following suspected serious injury', npj Mental Health Research, vol. 4, no. 1, 35. https://doi.org/10.1038/s44184-025-00153-7