Heparan sulfate facilitates Rift Valley fever virus entry into the cell
Publication date
2012
Authors
de Boer, S.M.
Kortekaas, J.
de Haan, Cornelis A M
Rottier, P.J.M.
Moormann, Rob
Bosch, Berend-Jan
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Abstract
Rift Valley fever virus (RVFV), an emerging arthropod-borne pathogen, has a broad host and cell tropism. Here we report that the glycosaminoglycan heparan sulfate, abundantly present on the surface of most animal cells, is required for efficient entry of RVFV. Entry was significantly reduced by preincubating the virus inoculum with highly sulfated heparin, by enzymatic removal of heparan sulfate from cells and in cells genetically deficient in heparan sulfate synthesis.
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de Boer, S M, Kortekaas, J, de Haan, C A M, Rottier, P J M, Moormann, R J M & Bosch, B J 2012, 'Heparan sulfate facilitates Rift Valley fever virus entry into the cell', Journal of Virology, vol. 86, no. 24, pp. 13767-13771. https://doi.org/10.1128/JVI.01364-12