N-glycosylation and glycoengineering in the mushroom-forming fungus Schizophyllum commune

Abstract

The market for N-glycosylated therapeutic proteins represents multi-billion dollars in sales and is growing more than 10% each year. As a consequence there is a need for cost-effective production platforms that display correct and homogeneous N-glycosylation. In this thesis, we investigate the use of mushroom forming basidiomycetes for the production of N-glycosylated therapeutic proteins