T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation
Publication date
2019-07-16
Authors
Fu, Ya Yuan
Egorova, Anastasiya
Sobieski, Catherine
Kuttiyara, Jason
Calafiore, Marco
Takashima, Shuichiro
Clevers, Hans
Hanash, Alan M.
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Document Type
Article
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taverne
Abstract
The key sites within the gastrointestinal tract where T cells mediate effector responses and their impact on intestinal stem cells remain unclear. Using 3D microscopy, Fu et al. visualize T cell spatial localization within the gastrointestinal tract, revealing the stem cell compartment as the primary intestinal target of allogeneic T cells during immune-mediated tissue damage occurring after bone marrow transplantation.
Keywords
allogeneic bone marrow transplantation, beta7 integrin, BMT, graft versus host disease, GVHD, imaging of immunity, intestinal stem cells, ISCs, LPAM, MAdCAM-1, mucosal immunology, Paneth cells, transplantation, Taverne, Immunology and Allergy, Immunology, Infectious Diseases
Citation
Fu, Y Y, Egorova, A, Sobieski, C, Kuttiyara, J, Calafiore, M, Takashima, S, Clevers, H & Hanash, A M 2019, 'T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation', Immunity, vol. 51, no. 1, pp. 90-103.e3. https://doi.org/10.1016/j.immuni.2019.06.003