New Viral and Immunological Targets for Hepatitis B Treatment and Cure: A Review
Publication date
2017-12-01
Authors
Arends, Joop E.
Lieveld, Faydra I.
Ahmad, Shazaad
Ustianowski, Andrew
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
cc_by_nc
Abstract
Although current therapies can be successful at suppressing hepatitis B viral load, long-term viral cure is not within reach. Subsequent strategies combining pegylated interferon alfa with nucleoside/nucleotide analogues have not resulted in any major paradigm shift. An improved understanding of the hepatitis B virus (HBV) lifec ycle and virus-induced immune dysregulation has, however, revealed many potential therapeutic targets, and there are hopes that treatment of hepatitis B could soon be revolutionized. This review summarizes the current developments in HBV therapeutics—both virus directed and host directed.
Keywords
Antiviral therapy, Hepatitis B virus, Immunomodulators, Nonnucleoside antivirals, Nucleoside analogues, Microbiology (medical), Infectious Diseases
Citation
Arends, J E, Lieveld, F I, Ahmad, S & Ustianowski, A 2017, 'New Viral and Immunological Targets for Hepatitis B Treatment and Cure : A Review', Infectious Diseases and Therapy, vol. 6, no. 4, pp. 461-476. https://doi.org/10.1007/s40121-017-0173-y