Sarcomas arising in MEN1 patients: demonstrating LOH of the MEN1 locus and loss of menin expression
Publication date
2024-11-28
Authors
van Leeuwaarde, Rachel S
Halfdanarson, Thorvardur R
Sudhakar, Shwetha M
Meijers, Ruud W J
Folpe, Andrew L
Brosens, Lodewijk A A
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Document Type
Article
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taverne
Abstract
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by endocrine tumors, typically from parathyroid, pancreatic, or anterior pituitary origin. In addition, benign cutaneous soft tissue tumors are prevalent in MEN1 patients. Although sarcomas have been reported in MEN1 patients it is unclear if these tumors should be considered as part of the MEN1 syndrome. Here, five patients with a MEN1 syndrome and a sarcoma are described. In all five sarcomas loss of heterozygosity of the MEN1 gene and loss of expression of menin are shown, suggesting that sarcomas may be a phenotypic expression of MEN1 syndrome.
Keywords
MEN1 gene, Multiple Endocrine Neoplasia Type 1, Sarcoma, Taverne, Genetics, Oncology, Genetics(clinical), Cancer Research
Citation
van Leeuwaarde, R S, Halfdanarson, T R, Sudhakar, S M, Meijers, R W J, Folpe, A L & Brosens, L A A 2024, 'Sarcomas arising in MEN1 patients : demonstrating LOH of the MEN1 locus and loss of menin expression', Familial cancer, vol. 24, no. 1, 10. https://doi.org/10.1007/s10689-024-00433-9