Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis
Files
Publication date
2016-01-02
Authors
Hermans, L. E.
Oosterheert, Jan Jelrik
Kampschreur, L. M.
Ossewaarde-Van Norel, J.
Dekkers, J.
Rothova, A.
de Groot-Mijnes, JDF
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
Purpose: Previous studies have suggested a link between Q fever and uveitis. We determined whether Coxiella burnetii causes intraocular infection in C. burnetii-seropositive patients with idiopathic uveitis. Methods: From a retrospective observational case series, paired aqueous humor and serum samples from 10 C. burnetii-seropositive patients with idiopathic uveitis were examined for intraocular antibody production by using the Goldmann-Witmer coefficient and by polymerase chain reaction (PCR). Results: Although intraocular IgG against C. burnetii was detected, no intraocular antibody production was observed (low Goldmann Wittmer coefficients). All PCR results were negative. Conclusions: Uveitis due to an intraocular infection with C. burnetii is unlikely.
Keywords
Aqueous humor analysis, Coxiella burnetii, infection, uveitis, Taverne, Ophthalmology, Immunology and Allergy, Journal Article, Research Support, Non-U.S. Gov't, Observational Study
Citation
Hermans, L E, Oosterheert, J J, Kampschreur, L M, Ossewaarde-Van Norel, J, Dekkers, J, Rothova, A & De Groot-Mijnes, J D F 2016, 'Molecular and Serological Intraocular Fluid Analysis of Coxiella burnetii-seropositive Patients with Concurrent Idiopathic Uveitis', Ocular Immunology and Inflammation, vol. 24, no. 1, pp. 77-80. https://doi.org/10.3109/09273948.2014.925123