Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers
Publication date
2024-12-24
Authors
Sanati, Mehdi
Figueroa-Espada, Christian G.
Han, Emily L.
Mitchell, Michael J.
Yavari, Saber Amin
Editors
Advisors
Supervisors
Document Type
Article
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taverne
Abstract
Chemoresistance remains a long-standing challenge after cancer treatment. Over the last two decades, RNA interference (RNAi) has emerged as a gene therapy modality to sensitize cancer cells to chemotherapy. However, the use of RNAi, specifically small-interfering RNA (siRNA), is hindered by biological barriers that limit its intracellular delivery. Nanoparticles can overcome these barriers by protecting siRNA in physiological environments and facilitating its delivery to cancer cells. In this review, we discuss the development of nanomaterials for siRNA delivery in cancer therapy, current challenges, and future perspectives for their implementation to overcome cancer chemoresistance.
Keywords
cancer, chemoresistance, chemotherapy, drug delivery, gene therapy, nanoparticles, nanotechnology, siRNA, Taverne, General Materials Science, General Engineering, General Physics and Astronomy
Citation
Sanati, M, Figueroa-Espada, C G, Han, E L, Mitchell, M J & Yavari, S A 2024, 'Bioengineered Nanomaterials for siRNA Therapy of Chemoresistant Cancers', ACS Nano, vol. 18, no. 51, pp. 34425–34463. https://doi.org/10.1021/acsnano.4c11259