Structure of the capsular antigen of Neisseria meningitidis serogroup K
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Publication date
1985
Authors
Vliegenthart, J.F.G.
Kaaden, A. van der
Gerwig, G.J.
Kamerling, J.P.
Tiesjema, R.H.
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Abstract
The capsular antigen isolated from the culture liquid of a Neisseria meningitidis serogroup K(1811) fermentation consists of the 2-acetamido-2-deoxymannuronic acid disaccharide repeating unit as follows: 3)-beta-d-ManpNAcA-(1->4)-beta-d-ManpNAcA-(1->
The polysaccharide is O-acetylated at the non-glycosylated C-4. Structural evidence has been obtained from sugar analysis, methylation analysis, as well as 1H and 13C NMR spectroscopy.