Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas
Publication date
2022-06-24
Authors
Rodon, Jordi
Mykytyn, Anna Z
Cantero, Guillermo
Albulescu, I C
Bosch, Berend Jan
Brix, Alexander
Audonnet, Jean-Christophe
Bensaid, Albert
Vergara-Alert, Júlia
Haagmans, Bart L
Editors
Advisors
Supervisors
Document Type
Article
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Abstract
Ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) continue posing a global health threat. Vaccination of livestock reservoir species is a recommended strategy to prevent spread of MERS-CoV among animals and potential spillover to humans. Using a direct-contact llama challenge model that mimics naturally occurring viral transmission, we tested the efficacy of a multimeric receptor binding domain (RBD) particle-display based vaccine candidate. While MERS-CoV was transmitted to naïve animals exposed to virus-inoculated llamas, immunization induced robust virus-neutralizing antibody responses and prevented transmission in 1/3 vaccinated, in-contact animals. Our exploratory study supports further improvement of the RBD-based vaccine to prevent zoonotic spillover of MERS-CoV.
Keywords
Animal model, Camelid, Llama, MERS-CoV, Middle East respiratory syndrome coronavirus, Multimeric protein scaffold particles (MPSP), Neutralizing antibodies, Receptor binding domain (RBD)-based vaccine, Virus transmission, SDG 3 - Good Health and Well-being
Citation
Rodon, J, Mykytyn, A Z, Cantero, G, Albulescu, I C, Bosch, B-J, Brix, A, Audonnet, J-C, Bensaid, A, Vergara-Alert, J, Haagmans, B L & Segalés, J 2022, 'Protective efficacy of an RBD-based Middle East respiratory syndrome coronavirus (MERS-CoV) particle vaccine in llamas', One Health Outlook, vol. 4, no. 1, 12, pp. 1-5. https://doi.org/10.1186/s42522-022-00068-9