Harnessing CRISPR to combat human viral infections
Publication date
2018-10
Authors
Buhr, H. J.
Lebbink, Robert Jan
Editors
Advisors
Supervisors
Document Type
Article
Metadata
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cc_by_nc_nd
Abstract
CRISPR/Cas9 is a technology that allows for targeted and precise genome editing in eukaryotic cells. The technique has changed the landscape of molecular biology and may be applied to repair genetic disorders in future therapies. Besides targeting the human genome, it can be used to cleave and edit viral DNA present in infected cells, and as such provides a promising new strategy for anti-viral therapy. Here, we discuss recent studies on the use of anti-viral CRISPRs to target pathogenic human viruses, with a focus on in vivo studies, challenges, and potential for future clinical applications.
Keywords
CRISPR-Cas Systems/genetics, Gene Editing/methods, Humans, Virus Diseases/genetics, Journal Article, Research Support, Non-U.S. Gov't, Review
Citation
de Buhr, H & Lebbink, R J 2018, 'Harnessing CRISPR to combat human viral infections', Current Opinion in Immunology, vol. 54, pp. 123-129. https://doi.org/10.1016/j.coi.2018.06.002