On the influence of orciprenaline on uterine motility and on plasma levels of estradiol-17β in pregnant and parturient sheep

Abstract

Orciprenaline infusions in laboring ewes suppressed uterine activity. A complete inhibition of uterine activity could only be obtained in the empty uterine horn of laboring ewes. During late pregnancy a complete inhibition of the pregnant horn could be established with orciprenaline doses much lower than those necessary during parturition. In all treated ewes, aberrant patterns of plasma estradiol-17β levels were observed: very high maternal estradiol-17β levels were detected after treatment with orciprenaline. It is suggested that orciprenaline influences fetal adrenocortical functioning.