Stereoselective one-pot synthesis of trans-3-amino-b-lactams from zinc enolates of N-protected a-aminoacid esters and imines

Abstract

A new one-pot synthesis of 3-amino@b-lactams that is based on the condensation of simple imines with zinc enolates of disilyl protected glycine esters is reported. Isolated yields are high and a trans-selectivity is observed.