DNA methylation differences in cortical grey and white matter in schizophrenia
Publication date
2021-08
Authors
Berdenis Van Berlekom, Amber
Notman, Nina
Sneeboer, Marjolein A.M.
Snijders, G.
Houtepen, Lotte C.
Nispeling, Danny M.
He, Yujie
Dracheva, Stella
Hol, Elly
Kahn, René S.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
taverne
Abstract
Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated from postmortem brain tissue of the superior temporal and medial frontal gyrus from SCZ (n = 10) and control (n = 11) cases. Genome-wide DNA-methylation analysis was performed using the Infinium EPIC Methylation Array (Illumina, CA, USA). Results: Four differentially methylated regions associated with SCZ status and tissue type (grey vs white matter) were identified within or near KLF9, SFXN1, SPRED2 and ALS2CL genes. Gene-expression analysis showed differential expression of KLF9 and SFXN1 in SCZ. Conclusion: Our data show distinct differences in DNA methylation between grey and white matter that are unique to SCZ, providing new leads to unravel the pathogenesis of SCZ.
Keywords
DNA-methylation, postmortem, schizophrenia, Taverne, Genetics, Cancer Research, Journal Article
Citation
Berdenis Van Berlekom, A, Notman, N, Sneeboer, M A M, Snijders, G J L J, Houtepen, L C, Nispeling, D M, He, Y, Dracheva, S, Hol, E M, Kahn, R S, De Witte, L D & Boks, M P 2021, 'DNA methylation differences in cortical grey and white matter in schizophrenia', Epigenomics, vol. 13, no. 15, pp. 1157-1169. https://doi.org/10.2217/epi-2021-0077