Hippocampal insulin resistance and cognitive dysfunction
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Publication date
2015-11-01
Authors
Biessels, Geert Jan
Reagan, Lawrence P.
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Supervisors
Document Type
Article
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taverne
Abstract
Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. Animal models of IR help to bridge these gaps and point to hippocampal IR as a potential mediator of cognitive dysfunction in T2DM, as well as in Alzheimer disease (AD). This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD.
Keywords
Taverne, General Neuroscience, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Review
Citation
Biessels, G J & Reagan, L P 2015, 'Hippocampal insulin resistance and cognitive dysfunction', Nature Reviews Neuroscience, vol. 16, no. 11, pp. 660-671. https://doi.org/10.1038/nrn4019