A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Publication date
2015
Authors
Vijai, Joseph
Wang, Zhaoming
Berndt, Sonja I
Skibola, Christine F
Slager, Susan L
de Sanjose, Silvia
Melbye, Mads
Glimelius, Bengt
Bracci, Paige M
Conde, Lucia
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Supervisors
Document Type
Article
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Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Keywords
Computational Biology, European Continental Ancestry Group, Genome-Wide Association Study, Genotype, Humans, Lymphoma, B-Cell, Marginal Zone, Major Histocompatibility Complex, Membrane Glycoproteins, Polymorphism, Single Nucleotide, Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
Citation
Vijai, J, Wang, Z, Berndt, S I, Skibola, C F, Slager, S L, de Sanjose, S, Melbye, M, Glimelius, B, Bracci, P M, Conde, L, Birmann, B M, Wang, S S, Brooks-Wilson, A R, Lan, Q, de Bakker, P I W, Vermeulen, R C H, Portlock, C, Ansell, S M, Link, B K, Riby, J, North, K E, Gu, J, Hjalgrim, H, Cozen, W, Becker, N, Teras, L R, Spinelli, J J, Turner, J, Zhang, Y, Purdue, M P, Giles, G G, Kelly, R S, Zeleniuch-Jacquotte, A, Ennas, M G, Monnereau, A, Bertrand, K A, Albanes, D, Lightfoot, T, Yeager, M, Chung, C C, Burdett, L, Hutchinson, A, Lawrence, C, Montalvan, R, Liang, L, Huang, J, Ma, B, Villano, D J, Maria, A, Corines, M, Thomas, T, Novak, A J, Dogan, A, Liebow, M, Thompson, C A, Witzig, T E, Habermann, T M, Weiner, G J, Smith, M T, Holly, E A, Jackson, R D, Tinker, L F, Ye, Y, Adami, H-O, Smedby, K E, De Roos, A J, Hartge, P, Morton, L M, Severson, R K, Benavente, Y, Boffetta, P, Brennan, P, Foretova, L, Maynadie, M, McKay, J, Staines, A, Diver, W R, Vajdic, C M, Armstrong, B K, Kricker, A, Zheng, T, Holford, T R, Severi, G, Vineis, P, Ferri, G M, Ricco, R, Miligi, L, Clavel, J, Giovannucci, E, Kraft, P, Virtamo, J, Smith, A, Kane, E, Roman, E, Chiu, B C H, Fraumeni, J F, Wu, X, Cerhan, J R, Offit, K, Chanock, S J, Rothman, N & Nieters, A 2015, 'A genome-wide association study of marginal zone lymphoma shows association to the HLA region', Nature Communications [E], vol. 6, 5751. https://doi.org/10.1038/ncomms6751