GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins
Files
Publication date
2014-11-19
Authors
Dorobantu, Cristina M
Ford-Siltz, Lauren A
Sittig, Simone P
Lanke, Kjerstin H W
Belov, George A
van Kuppeveld, Frank J M
van der Schaar, H.M.
Editors
Advisors
Supervisors
Document Type
Article
Metadata
Show full item recordCollections
License
Abstract
PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses like poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although previously HRV 3A was shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.
Keywords
Coronacrisis-Taverne, SDG 3 - Good Health and Well-being
Citation
Dorobantu, C M, Ford-Siltz, L A, Sittig, S P, Lanke, K H W, Belov, G A, van Kuppeveld, F J M & van der Schaar, H M 2014, 'GBF1- and ACBD3-independent recruitment of PI4KIIIβ to replication sites by rhinovirus 3A proteins', Journal of Virology. https://doi.org/10.1128/JVI.02830-14